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Chemical Engineering

Carlos Escobedo

Assistant Professor

Tel: (613) 533-3095
Fax: (613) 533-6637
Email: carlos.escobedo@queensu.ca
Office: Dupuis Hall Room 209

Main

Research Interests

Our research involves the development of miniaturized technologies for analytical and diagnostic applications through the use and combination of microfluidics and optics. We pursue the development of novel technologies for user-based applications of high socio-economic relevance and technologies with unique abilities that facilitate scientific advances in chemistry, biology and medicine.

We approach technology development through the study of fundamental problems at the micro- and nanoscale, computational modelling and experimentation. Our research is inherently multidisciplinary and is particularly applicable to label-free sensing requiring real-time measurements in situ.

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Last updated Jan 1, 2013.

Publications

Publications

Journal Articles

  • B. Sorce, C. Escobedo, Y. Toyoda, M. Stewart, C. J. Cattin, I. Banerjee, R. Newton, A. Stettler, A. A. Hyman, A. Hierlemann, D. J. Müller* “Be Stronger or Run: Mitotic cells generate pressure to round up against or to escape epithelial confinement”,  Nature Communications (in press).
  • Bürgel, S., Escobedo, C., Kemmerling, S., Braun, T., Hierlemann, A.* (2015) “On-chip electroporation and impedance spectroscopy of single-cells”, Sensors and Actuators B. Chemical, 210, 82-90.Escobedo, C. (2013) "On-chip nanohole array based sensing: a review", Lab on a Chip, 13, 2445-2463. Open Source
  • Kemmerling, S., Stefan, A., Benjamin, B., Sauter, N., Escobedo, C., Hierlemann, A., Stahlberg, H., Braun, T. (2013) "Single-cell lysis for visual proteomics", Journal of Structural Biology, 183 (3), 467-473.
  • Escobedo, C., Chou Y., Rahman M., Xiaobo D., Gordon, R., Sinton, D., Brolo, A. G., Ferreira, J. (2013) "Microfluidic concentration gradient generator integrated on nanohole array imaging for in situ quantification of ovarian cancer Markers", Analyst, 138, 1450.
  • Escobedo, C., Brolo, A. G., Gordon, R., Sinton, D. (2012) "Optofluidic concentration: Plasmonic nanostructure as concentrator and sensor", Nano Letters, 12 (3), 1592-1596.
  • Fan, M., Wang, P., Escobedo, C., Sinton, D., Brolo, A. G. (2012) "Surface-Enhanced Raman Scattering (SERS) Optrodes for Multiplexed On-Chip Sensing for Multiplexed On-Chip Sensing of Nile Blue A and Oxazine 720", Lab on a Chip, 12 (8), 1554-1560.
  • Escobedo, C., Vincent, S., Choudhury, A. I. K., Campbell, J., Brolo, A. G., Sinton, D., Gordon, R. (2011) "Integrated Nanohole Array Surface Plasmon Resonance Sensing Device using a Dual-Wavelength Source", Journal of Micromechanics and Microengineering, 21, 115001, 6 pp. [Highlights of 2011]
  • Escobedo, C., Sinton, D. (2011) "Microfluidic Liquid Actuation through Ground-directed Electric Discharge", Microfluidics and Nanofluidics, 11, 653-662.
  • Scarff, B., Escobedo, C., Sinton, D. (2011) "Radial Sample Preconcentration", Lab on a Chip, 11, 1102-1109.
  • Escobedo, C., Brolo, A. G., Gordon, R., Sinton, D. (2010) "Flow-Through vs. Flow-Over: Analysis of Transport and Binding in Nanohole Array Plasmonic Biosensors", Analytical Chemistry, 82(24), 10015-10020. [Featured in Optics and Photonics News, November 2010]
  • Sacristan, C., Escobedo, C., Bojalil, R., Izaguirre, R., Cortina, E., Aranda, A., Catrip, J., Lespron, M. C., Springall, R., Sacristan, E. (2010) "In vivo Assessment of Hemocompatibility of a Ventri-Cular Assist Device in Healthy Swine - Measurement of Inflammatory Parameters", Archivos de Cardiologia de Mexico, 80(2), 67-76.
  • Eftekhari‡, F., Escobedo‡, C., Ferreira, J., Duan, X., Girotto, E. M., Brolo, A. G., Gordon, R., Sinton, D. (2009) "Nanoholes as Nanochannels: Flow-Through Plasmonic Sensing", Analytical Chemistry, 81(11), 4308-4311. [Featured in in Nature Photonics 5, 591-597 (2011) and in Nanowerk, (2009)]
  • Ren, L., Escobedo, C., Li, D. (2002) "A New Method of Evaluating the Average Electroosmotic Velocity in Microchannels", A New Method of Evaluating the Average Electro-Osmotic Velocity in Microchannels", Journal of Colloid and Interface Science, 254:184-189.
  • Sinton, D., Escobedo-Canseco, C., Ren, L., Li, D. (2002) "Direct and Indirect Electroosmotic Flow Velocity Measurement in Microchannels", Journal of Colloid and Interface Science, 254, 238-242.
  • Ren, L., Escobedo, C., Li, D. (2001) "Electroosmotic Flow in a Mirocapillary with One Solution Displacing Another Solution", Journal of Colloid and Interface Science, 242, 264-271.

Patents

  • Escobedo C. et al, (2011), U.S. Patent Application No. 13/110,598.

Selected Proceedings, Conference Publications and Presentations

  • Escobedo, C., Gordon, R., Brolo, A. G., Sinton, D., "Flow-through nanohole arrays for biomarker concentration and sensing", Biosensors 2012, Cancun, Mexico, 15-18 May 2012.
  • Escobedo, C., Burgel, S., Kemmerling, S., Zhu, Z., Gerspach, M., Stettler, A., Frey, O., Hierlemann, A., "On-chip Lysis using Corona Discharge", Biosensors 2012, Cancun, Mexico, 15-18 May 2012.
  • Escobedo, C., Scarff, B., Brolo, A.G., Gordon, R., Sinton, D. (2011) "Dual-Function Metallic Nanohole Arrays: Electrokinetic Analyte Concentration and Plasmonic Sensing", CLEO: 2011 - Laser Science to Photonic Applications, Baltimore, MD, USA, 1-6 May 2011.
  • Escobedo, C., Brolo, A., Gordon, R., Sinton, D. (2011) "Nanoplasmonics as nanofluidics: transport and sensing in flowthrough nanohole arrays", Proceeding of SPIE Photonics West, San Francisco, CA, 7929, 7929Q-10.
  • Escobedo, C., Sinton, D. "Directed Corona Discharge for Microfluidic Liquid Actuation and Control," Proceedings of IMECE2010, 2010 ASME International Mechanical Engineering Congress and Exposition, Vancouver, BC, November 2010. [Best Presentation Award]
  • Escobedo, C., Brolo, A. G., Gordon, R., Sinton, D. "Optofluidic Sieving with Flow-Through Plasmonic Nanohole Arrays," Conference on Lasers and Electro-Optics (CLEO) and Quantum Electronics and Laser Science Conference (QELS), San Jose, CA, May 2010. [Featured in Optics and Photonics News, November 2010]
  • Escobedo, C., Wood, P., Gordon, R., Brolo, A. G., Sinton, D. "Flow-Through Nanohole Array Based Sensing," Proceedings of the SPIE, Vol. 7322, 732206 (13 pp.), ASME International Mechanical Engineering Conference and Exposition, Lake Buena Vista, FL, November 2009.
  • Escobedo, C., Ferreira, J., Eftekhari, F., Gordon, R., Brolo, A. G., Sinton, D. "Solid and fluid mechanics of flow-through nanohole array based sensing," PCAMM Annual Meeting, Victoria, B.C., Canada, November 2008.
  • Escobedo, C., Eftekhari, F., Ferreira, J., Wood, P., Gordon, R., Brolo, A. G., Sinton, D. "Nanohole arrays as optical and fluidic elements for sensing," Proceedings of The ASME International Mechanical Engineering Congress and Exposition, Vol 13, pp. 965-969, Boston, MA, October 2008.