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Chemical Engineering

Carlos Escobedo

Assistant Professor

Tel: (613) 533-3095
Fax: (613) 533-6637
Email: carlos.escobedo@queensu.ca
Office: Dupuis Hall Room 209

Main

Research Interests

Our research involves the development of miniaturized technologies for analytical and diagnostic applications through the use and combination of microfluidics and optics. We pursue the development of novel technologies for user-based applications of high socio-economic relevance and technologies with unique abilities that facilitate scientific advances in chemistry, biology and medicine.

We approach technology development through the study of fundamental problems at the micro- and nanoscale, computational modelling and experimentation. Our research is inherently multidisciplinary and is particularly applicable to label-free sensing requiring real-time measurements in situ.

Education

  • Postdoctoral fellow – Swiss Institute of Technology (ETH) Zurich (2013)
  • Ph.D. – University of Victoria (2011)
  • M.A.Sc. – University of Toronto (2002)
  • B.Sc. – UNAM (2000)

Funding

  • NSERC Discovery Grants
  • CFI Leaders Opportunity Fund
  • NSERC Engage
  • CFI Infrastructure Operating Fund
  • Queen’s Research Opportunities Fund
  • Queen’s SARC fund
  • Ontario Research Fund (ORF)
  • Canada-Latin America Research Exchange Grants (LACREG) Program International Development Research Centre

Lab website: www.escobedolab.com

Last updated Feb 27/17

Publications

Journal Articles

  • S. Nair, C. Escobedo* and R. G. Sabat* (2016) "Crossed Surface Relief Gratings as Nanoplasmonic Biosensors", ACS Sensors. (accepted, published online)
  • Z. Zhu, P. Chen, K. Liu, C. Escobedo (2016) "A Versatile Bonding Method for PDMS and SU-8 and Its Application towards a Multifunctional Microfluidic Device", Micromachines, 7, x. (published online)
  • B. Sorce, C. Escobedo, Y. Toyoda, M. Stewart, C. J. Cattin, I. Banerjee, R. Newton, A. Stettler, A. A. Hyman, A. Hierlemann, D. J. Müller* “Be Stronger or Run: Mitotic cells generate pressure to round up against or to escape epithelial confinement”,  Nature Communications (in press).
  • Bürgel, S., Escobedo, C., Kemmerling, S., Braun, T., Hierlemann, A.* (2015) “On-chip electroporation and impedance spectroscopy of single-cells”, Sensors and Actuators B. Chemical, 210, 82-90.Escobedo, C. (2013) "On-chip nanohole array based sensing: a review", Lab on a Chip, 13, 2445-2463. Open Source
  • Kemmerling, S., Stefan, A., Benjamin, B., Sauter, N., Escobedo, C., Hierlemann, A., Stahlberg, H., Braun, T. (2013) "Single-cell lysis for visual proteomics", Journal of Structural Biology, 183 (3), 467-473.
  • Escobedo, C., Chou Y., Rahman M., Xiaobo D., Gordon, R., Sinton, D., Brolo, A. G., Ferreira, J. (2013) "Microfluidic concentration gradient generator integrated on nanohole array imaging for in situ quantification of ovarian cancer Markers", Analyst, 138, 1450.
  • Escobedo, C., Brolo, A. G., Gordon, R., Sinton, D. (2012) "Optofluidic concentration: Plasmonic nanostructure as concentrator and sensor", Nano Letters, 12 (3), 1592-1596.
  • Fan, M., Wang, P., Escobedo, C., Sinton, D., Brolo, A. G. (2012) "Surface-Enhanced Raman Scattering (SERS) Optrodes for Multiplexed On-Chip Sensing for Multiplexed On-Chip Sensing of Nile Blue A and Oxazine 720", Lab on a Chip, 12 (8), 1554-1560.
  • Escobedo, C., Vincent, S., Choudhury, A. I. K., Campbell, J., Brolo, A. G., Sinton, D., Gordon, R. (2011) "Integrated Nanohole Array Surface Plasmon Resonance Sensing Device using a Dual-Wavelength Source", Journal of Micromechanics and Microengineering, 21, 115001, 6 pp. [Highlights of 2011]
  • Escobedo, C., Sinton, D. (2011) "Microfluidic Liquid Actuation through Ground-directed Electric Discharge", Microfluidics and Nanofluidics, 11, 653-662.
  • Scarff, B., Escobedo, C., Sinton, D. (2011) "Radial Sample Preconcentration", Lab on a Chip, 11, 1102-1109.
  • Escobedo, C., Brolo, A. G., Gordon, R., Sinton, D. (2010) "Flow-Through vs. Flow-Over: Analysis of Transport and Binding in Nanohole Array Plasmonic Biosensors", Analytical Chemistry, 82(24), 10015-10020. [Featured in Optics and Photonics News, November 2010]
  • Sacristan, C., Escobedo, C., Bojalil, R., Izaguirre, R., Cortina, E., Aranda, A., Catrip, J., Lespron, M. C., Springall, R., Sacristan, E. (2010) "In vivo Assessment of Hemocompatibility of a Ventri-Cular Assist Device in Healthy Swine - Measurement of Inflammatory Parameters", Archivos de Cardiologia de Mexico, 80(2), 67-76.
  • Eftekhari‡, F., Escobedo‡, C., Ferreira, J., Duan, X., Girotto, E. M., Brolo, A. G., Gordon, R., Sinton, D. (2009) "Nanoholes as Nanochannels: Flow-Through Plasmonic Sensing", Analytical Chemistry, 81(11), 4308-4311. [Featured in in Nature Photonics 5, 591-597 (2011) and in Nanowerk, (2009)]
  • Ren, L., Escobedo, C., Li, D. (2002) "A New Method of Evaluating the Average Electroosmotic Velocity in Microchannels", A New Method of Evaluating the Average Electro-Osmotic Velocity in Microchannels", Journal of Colloid and Interface Science, 254:184-189.
  • Sinton, D., Escobedo-Canseco, C., Ren, L., Li, D. (2002) "Direct and Indirect Electroosmotic Flow Velocity Measurement in Microchannels", Journal of Colloid and Interface Science, 254, 238-242.
  • Ren, L., Escobedo, C., Li, D. (2001) "Electroosmotic Flow in a Mirocapillary with One Solution Displacing Another Solution", Journal of Colloid and Interface Science, 242, 264-271.

Patents

  • Escobedo C. et al, (2011), U.S. Patent Application No. 13/110,598.
  • H. Dies, C. Escobedo and A. Docoslis, US Patent Application 62/373,537. 2016/09/16.

Selected Proceedings, Conference Publications and Presentations

  • Escobedo, C., Gordon, R., Brolo, A. G., Sinton, D., "Flow-through nanohole arrays for biomarker concentration and sensing", Biosensors 2012, Cancun, Mexico, 15-18 May 2012.
  • Escobedo, C., Burgel, S., Kemmerling, S., Zhu, Z., Gerspach, M., Stettler, A., Frey, O., Hierlemann, A., "On-chip Lysis using Corona Discharge", Biosensors 2012, Cancun, Mexico, 15-18 May 2012.
  • Escobedo, C., Scarff, B., Brolo, A.G., Gordon, R., Sinton, D. (2011) "Dual-Function Metallic Nanohole Arrays: Electrokinetic Analyte Concentration and Plasmonic Sensing", CLEO: 2011 - Laser Science to Photonic Applications, Baltimore, MD, USA, 1-6 May 2011.
  • Escobedo, C., Brolo, A., Gordon, R., Sinton, D. (2011) "Nanoplasmonics as nanofluidics: transport and sensing in flowthrough nanohole arrays", Proceeding of SPIE Photonics West, San Francisco, CA, 7929, 7929Q-10.
  • Escobedo, C., Sinton, D. "Directed Corona Discharge for Microfluidic Liquid Actuation and Control," Proceedings of IMECE2010, 2010 ASME International Mechanical Engineering Congress and Exposition, Vancouver, BC, November 2010. [Best Presentation Award]
  • Escobedo, C., Brolo, A. G., Gordon, R., Sinton, D. "Optofluidic Sieving with Flow-Through Plasmonic Nanohole Arrays," Conference on Lasers and Electro-Optics (CLEO) and Quantum Electronics and Laser Science Conference (QELS), San Jose, CA, May 2010. [Featured in Optics and Photonics News, November 2010]
  • Escobedo, C., Wood, P., Gordon, R., Brolo, A. G., Sinton, D. "Flow-Through Nanohole Array Based Sensing," Proceedings of the SPIE, Vol. 7322, 732206 (13 pp.), ASME International Mechanical Engineering Conference and Exposition, Lake Buena Vista, FL, November 2009.
  • Escobedo, C., Ferreira, J., Eftekhari, F., Gordon, R., Brolo, A. G., Sinton, D. "Solid and fluid mechanics of flow-through nanohole array based sensing," PCAMM Annual Meeting, Victoria, B.C., Canada, November 2008.
  • Escobedo, C., Eftekhari, F., Ferreira, J., Wood, P., Gordon, R., Brolo, A. G., Sinton, D. "Nanohole arrays as optical and fluidic elements for sensing," Proceedings of The ASME International Mechanical Engineering Congress and Exposition, Vol 13, pp. 965-969, Boston, MA, October 2008.

Teaching

CHEE 912 Applied Lab-on-Chip Technologies

This 6 week (3 hours/week) module will provide an overview on the latest developments, fabrication techniques, and principles of operation of contemporary micro- and nanotechnologies used in lab-on-chip (LOC) type platforms. Small-scale subunit operations required in LOC systems, equally relevant across several disciplines in both life sciences and engineering fields, will be covered in detail. The knowledge acquired in these topics will be used during the last part of the course to analyze the design of LOC-based systems in key applications in different areas including biosensing, biotechnology and emerging energy technologies.

CHEE 223 Fluid Mechanics

Principles of mass, momentum and energy transport are applied to the analysis of fluid systems commonly encountered in chemical engineering practice. This approach is via the macroscopic and differential balances of mass, momentum and energy. Topics include fluid statics, incompressible flow in closed conduits, flow and pressure measurement, transportation of fluids, laminar, turbulent and creeping flows, and boundary layer effects. The design component of this course involves the determination of commercial components (piping, tubing, valves, pressure and flow meters and other fittings, as well as pumps) for fluid transport systems in industrial settings.

CHEE 224 Transport Phenomena Fundamentals

The theory and mathematical framework of transport phenomena are introduced. Mass, energy and momentum balances are developed using the integral and differential methods of analysis. The tools used to formulate and solve the problems include representation of physical entities in vector form, multivariable functions and vector operations in 2D and 3D. Specific topics of Chemical Engineering interest include moments of a force, work done by a force, moments of inertia, control surfaces and control volumes and fluid kinematics (21/0/0/21/0).