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Chemical Engineering

Lindsay Fitzpatrick

Lindsay Fitzpatrick

Assistant Professor

Tel: (613) 533-6000x78936
Fax: (613) 533-6637
Email: lindsay.fitzpatrick@queensu.ca
Office: Biosciences 4630

Research Site: Fitzpatrick Lab

Lindsay Fitzpatrick

Main

Research Interests

My research program explores the interactions among biomaterials, innate immune cells and adsorbed proteins to better understand the underlying mechanisms that drive host responses to implanted biomedical materials and devices. Specifically, we are interested in defining the contributions tissue-derived proteins and other macromolecules within adsorbed protein layers on biomaterial surfaces, and studying activation of pattern recognition pathways in responding inflammatory cells, such as macrophages. The goal of our research is advance biomaterial science and improve material-tissue integration by better understanding the mechanisms driving host responses and foreign body reactions. In parallel, we are also developing rapid-throughput models for screening novel biomaterial candidates through non-invasive imaging to assess biocompatibility and host responses, as well as in vivo material characterization.

Fitzpatrick Lab trainees are eligible to apply to the Queen's Collaborative Biomedical Engineering (CBME) graduate program.

Education

  • Postdoc - Georgia Institute of Technology (2013) 
  • PhD - University of Toronto (2012)
  • B.Eng and Biosciences - McMaster University (2006)

Funding

  • Queen's University
  • NSERC (Discovery)
  • Canada Foundation for Innovation (JELF)
  • Ontario Ministry of Research and Innovation (ORF)

Publications

Journal Articles

  1. Fitzpatrick LE*, McDevitt TC. (2015) Cell-derived matrices for tissue engineering and regenerative medicine applications. Biomaterials Science. 3(1): 12-24.  
    • Recommended in F1000Prime as being of special significance in its field
    • Top 20 most-accessed Biomaterials Science articles in 2015; Top 10 Most-accessed Biomaterials Science articles – Q1 2016
  2. Fitzpatrick LE, Lisovsky A and Sefton MV. (2012) The expression of sonic hedgehog in diabetic wounds following treatment with poly(methacrylic acid-co-methyl methacrylate) beads. Biomaterials 33(21):5297-5307.
  3. Fitzpatrick SD, Fitzpatrick LE, Thakur A, Mazumder MAJ and Sheardown H. (2012) Temperature-sensitive polymers for drug delivery. Expert Review of Medical Devices 9(4):339-351.
  4. Fitzpatrick LE, Chan JWY and Sefton MV. (2011) On the mechanism of poly(methacrylic acid –co– methyl methacrylate)-induced angiogenesis: gene expression analysis of dTHP-1 cells. Biomaterials32(34): 8957-8967.
  5. Corstorphine L and Sefton MV. (2011) Effectiveness factor and diffusion limitations in collagen gel modules containing HepG2 cells. Journal of tissue engineering and regenerative medicine5(2): 119-129.
  6. Fitzpatrick SD, Jafar Mazumder MA, Lasowski F, Fitzpatrick LE, Sheardown H. (2010) PNIPAAm-grafted-collagen as an injectable, in situ gelling, bioactive cell delivery scaffold. Biomacromolecules. 11(9): 2261-2267.
  7. Chamberlain MD, Butler MJ, Ciucurel EC, Fitzpatrick LE, Khan OF, Leung BM, Lo C, Patel R, Velchinskaya A, Voice DN, Sefton MV. (2010) Fabrication of micro-tissues using modules of collagen gel containing cells. Journal of Visualized Experiments. 13;(46).

Book Chapters

  1. Antonyshyn JA, Fitzpatrick LE* (2016) Stem cell and stem cell-derived molecular therapies to enhance dermal wound healing. In Singh A and Gaharwar AK (Eds.) Microscale Technologies for Cellular Engineering. Springer International Publishing (in press). (* Corresponding Author)
  2. Fitzpatrick LE#, Lisovsky A#, Ciucurel EC and Sefton MV (2014) Scaffold vascularization. In Migliaresi C and Motta A (Eds.) Scaffolds for tissue engineering: biological design, materials and fabrication. Pan Stanford Publishing. (# Denotes co-first author)

(* corresponding author)

Teaching

CHEE 340: Biomedical Engineering

This course will introduce students to the fundamentals necessary to understand and appreciate the issues involved in engineering in the body and to provide a framework for upper level studies in the area. Topics include: Anatomy and Physiology, Transport Phenomena in the Body, Biomechanics, Materials in Medicine, and Regenerative Medicine and Tissue Engineering.

CHEE 874: Tissue Engineering

This course is designed as a graduate level introductory course in tissue engineering: the interdisciplinary field that encompasses biology, chemistry, medical sciences and engineering to design and fabricate living systems to replace damaged or diseased tissues and organs. Topics to be discussed include: tissue anatomy, basic cell biology, cell scaffolds, cell sources and differentiation, design considerations, diffusion and mass transfer limitations, effects of external stimuli, bioreactors, methods used to evaluate the engineered product(s), and implantation. Case studies of specific tissue engineering applications will also be discussed. Students will be required to participate in, as well as lead, discussions on the course material and relevant journal articles.